个人简介 Personal Profile

杨竹，女，1964年10月出生，汉族，重庆江津人，博士研究生学历，博士，二级教授，博士生导师；现任爱体育「中国」官方网站教育部“生殖与发育国际合作联合实验室”主任、重庆市女科技工作协会会长。历任爱体育「中国」官方网站副校长，爱体育「中国」官方网站附属第二医院院长办公室主任，爱体育「中国」官方网站科研处处长，生命科学研究院副院长（主持工作）、药学院院长（兼）、缙云校区管委会主任（兼）、分子医学检测中心主任。

杨竹教授长期从事医学临床、医学教育、医学科研、医学管理工作、主持科技部支撑计划项目、国家自然科学基金面上项目以及重庆市科技局重点项目等科研项目10余项。发表科技论文140余篇，获得重庆市政府科技进步一等奖，重庆市卫生健康委员会医学科技一等奖，重庆市医学杰出贡献奖等。

工作经历

2015.08 至今 爱体育「中国」官方网站附属第二医院妇产科 主任医师

2011.07 至 2024.10 爱体育「中国」官方网站副校长

2011.12 至今 爱体育「中国」官方网站, 博士生导师

2008.07 至今 爱体育「中国」官方网站附属第二医院妇产科，研究员

2003.10 至 2015.08 爱体育「中国」官方网站附属第二医院妇产科，副主任医师

1993.10 至 2003.10 爱体育「中国」官方网站附属第二医院妇产科, 主治医师

1988.07 至 1993.10 爱体育「中国」官方网站附属第二医院妇产科，住院医师

教育经历

1999.09 至 2004.07 爱体育「中国」官方网站, 妇产科学，硕博连读, 导师: 胡丽娜

1982.09 至 1988.06 华西医科大学, 医学系，学士

研究方向 Research Interests

（1）卵巢癌的发病机制研究

（2）多囊卵巢综合征的发病机制研究

（3）绝经女性骨质疏松的预防与临床治疗研究

实验室科研项目 Projects

在研科研项目

无

已结题项目

（1）国家自然科学基金面上项目（《超声破坏携OSP1-TK病毒载体的微泡对卵巢癌的靶向治疗作用及机制研究》，30973169）主持

（2）国家科技支撑计划项目（《慢性支气管炎等疾病防治技术研究》，2007BAI07A08），主持

（3）国家食品药品监督管理总局药品评价中心项目（基于电子诊疗数据的注射剂严重过敏反应主动监测研究），主持

（4）重庆市科学技术局技术创新与应用发展（重大项目）（《新冠中和抗体联合鼻喷剂（A8G6）循证医学证据建立研究》，CSTB2022TIAD-STX0013），主持

代表性科研论文 Publications

( *：co-corresponding authors 共同通讯作者; #：co-first authors 共同第一作者)

1.Zheng J, Sun Y, Long T, Yuan D, Yue S, Zhang N, Yang Z. Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation. Drug Deliv. 2022 Dec;29(1):1164-1175. doi: 10.1080/10717544.2022.2058653. PMID: 35393920; PMCID: PMC9004507.

2.Wang M, Yue S, Yang Z. Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma. Sci Rep. 2023 Mar 11;13(1):4081. doi: 10.1038/s41598-023-31325-0. PMID: 36906716; PMCID: PMC10008565.

3.Zhang S, Li Q, Ouyang X, Tang Y, Cui J, Yang Z. Radiotherapy can improve overall survival in patients with lymph-node positive, high-grade neuroendocrine cervical cancer: construction of two prognostic nomograms to predict treatment outcome. Front Oncol. 2024 Sep 13;14:1450382. doi: 10.3389/fonc.2024.1450382. PMID: 39346736; PMCID: PMC11427233.

4.Zhao H, He W, Yang Z. A pairwise and network meta-analysis comparing the efficacy and safety of progestogens in threatened abortion. Int J Gynaecol Obstet. 2022 Mar;156(3):383-393. doi: 10.1002/ijgo.13707. Epub 2021 May 18. PMID: 33864694.

5.Zhao H, He W, Xia C, Yang Z. Efficacy and safety of different progestogens in women with first threatened miscarriage: A network meta-analysis. Int J Gynaecol Obstet. 2025 Mar;168(3):944-957. doi: 10.1002/ijgo.15987. Epub 2024 Dec 19. PMID: 39698935.

6.Dong X, Yang Z. High-intensity focused ultrasound ablation of uterine localized adenomyosis. Curr Opin Obstet Gynecol. 2010 Aug;22(4):326-30. doi: 10.1097/GCO.0b013e32833bea2e. PMID: 20610999.

7.Liang X, Liu Y, Zeng L, Yu C, Hu Z, Zhou Q, Yang Z. miR-101 inhibits the G1-to-S phase transition of cervical cancer cells by targeting Fos. Int J Gynecol Cancer. 2014 Sep;24(7):1165-72. doi: 10.1097/IGC.0000000000000187. PMID: 24987920.

8.Yue S, He Y, Wang M, Liu X, Li X, Zhao B, Yi Q, Li Q, Yu Q, Yang Z. Enhancement of sonodynamic treatment of ovarian cancer based on Pt-B-P ternary nanoparticles. Nanomedicine. 2023 Jul;51:102686. doi: 10.1016/j.nano.2023.102686. Epub 2023 Apr 29. PMID: 37121459.

9.Yuan D, Luo J, Sun Y, Hao L, Zheng J, Yang Z. PCOS follicular fluid derived exosomal miR-424-5p induces granulosa cells senescence by targeting CDCA4 expression. Cell Signal. 2021 Sep;85:110030. doi: 10.1016/j.cellsig.2021.110030. Epub 2021 Apr 28. PMID: 33930499.

10.Sun Y, Hao L, Han W, Luo J, Zheng J, Yuan D, Ye H, Li Q, Huang G, Han T, Yang Z. Intrafollicular fluid metabolic abnormalities in relation to ovarian hyperstimulation syndrome: Follicular fluid metabolomics via gas chromatography-mass spectrometry. Clin Chim Acta. 2023 Jan 1;538:189-202. doi: 10.1016/j.cca.2022.11.033. Epub 2022 Dec 22. PMID: 36566958.

11.Luo J, Ye H, Hao L, Sun Y, Li R, Li Y, Yang Z. SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS. Genes Dis. 2019 Sep 17;8(1):94-109. doi: 10.1016/j.gendis.2019.09.005. PMID: 33569518; PMCID: PMC7859457.

12.Song J, Zhang N, Zhang L, Yi H, Liu Y, Li Y, Li X, Wu M, Hao L, Yang Z, Wang Z. IR780-loaded folate-targeted nanoparticles for near-infrared fluorescence image-guided surgery and photothermal therapy in ovarian cancer. Int J Nanomedicine. 2019 Apr 18;14:2757-2772. doi: 10.2147/IJN.S203108. PMID: 31118609; PMCID: PMC6503636.

13.Yang HM, Yu C, Yang Z. N-acetylglucosaminyltransferase V negatively regulates integrin α5β1-mediated monocyte adhesion and transmigration through vascular endothelium. Int J Oncol. 2012 Aug;41(2):589-98. doi: 10.3892/ijo.2012.1484. Epub 2012 May 17. PMID: 22614033.

14.Song J, Zhang L, Yi H, Huang J, Zhang N, Zhong Y, Hao L, Ke Yang, Wang Z, Wang D, Yang Z. NIR-responsive nanoplatform for pre/intraoperative image-guided carcinoma surgery and photothermal ablation of residual tumor tissue. Nanomedicine. 2019 Aug;20:102020. doi: 10.1016/j.nano.2019.102020. Epub 2019 May 22. PMID: 31125675.

15.Wang M, Sun Y, Yuan D, Yue S, Yang Z. Follicular fluid derived exosomal miR-4449 regulates cell proliferation and oxidative stress by targeting KEAP1 in human granulosa cell lines KGN and COV434. Exp Cell Res. 2023 Sep 15;430(2):113735. doi: 10.1016/j.yexcr.2023.113735. Epub 2023 Jul 29. PMID: 37517590.

16.Xiang S, Wang M, Li Q, Yang Z. Unveiling the role of HACE1 in cervical cancer: implications for human papillomavirus infection and prognosis. Transl Cancer Res. 2024 May 31;13(5):2175-2186. doi: 10.21037/tcr-23-2120. Epub 2024 May 20. PMID: 38881936; PMCID: PMC11170517.

17.Yang Z, Cao YD, Hu LN, Wang ZB. Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis. Fertil Steril. 2009 Jun;91(6):2338-43. doi: 10.1016/j.fertnstert.2008.03.017. Epub 2008 Apr 28. PMID: 18440527.

18.Jin FZ, Yu C, Zhao DZ, Wu MJ, Yang Z. A correlation between altered O-GlcNAcylation, migration and with changes in E-cadherin levels in ovarian cancer cells. Exp Cell Res. 2013 Jun 10;319(10):1482-90. doi: 10.1016/j.yexcr.2013.03.013. Epub 2013 Mar 22. PMID: 23524144.

19.Cui J, Zhai Q, Chen M, Yang Z. Genetically predicted lipids mediate the association between intrahepatic cholestasis of pregnancy and cardiovascular disease. Front Cardiovasc Med. 2024 Apr 30;11:1401010. doi: 10.3389/fcvm.2024.1401010. Erratum in: Front Cardiovasc Med. 2024 Jul 18;11:1439868. doi: 10.3389/fcvm.2024.1439868. PMID: 38745758; PMCID: PMC11091286.

20.Li Y, Yu Q, Li R, Luo J, Yuan D, Song J, Sun Y, Long T, Yang Z. SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway. Onco Targets Ther. 2019 Nov 6;12:9239-9248. doi: 10.2147/OTT.S215940. PMID: 31819473; PMCID: PMC6847988.

21.Wang LY, Li LS, Yang Z. Correlation of FOXC1 protein with clinicopathological features in serous ovarian tumors. Oncol Lett. 2016 Feb;11(2):933-938. doi: 10.3892/ol.2015.3996. Epub 2015 Dec 3. PMID: 26893671; PMCID: PMC4734046.

22.Wang R, Yu C, Zhao D, Wu M, Yang Z. The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13. Oncol Rep. 2013 Aug;30(2):667-76. doi: 10.3892/or.2013.2493. Epub 2013 May 24. PMID: 23708057.

23.Li Q, Sheng M, Chen Y, Yi Q, Yang Z, Chen T. Comprehensive immunogenomic landscape analysis unveils CD33 + myeloid cell-driven immunomodulatory signatures in melanoma development. Pathol Res Pract. 2025 Jun;270:155981. doi: 10.1016/j.prp.2025.155981. Epub 2025 Apr 16. PMID: 40300524.

24.Liu Y, Long T, Zhang N, Qiao B, Yang Q, Luo Y, Cao J, Luo J, Yuan D, Sun Y, Li Y, Yang Z, Wang ZG. Ultrasound-Mediated Long-Circulating Nanopolymer Delivery of Therapeutic siRNA and Antisense MicroRNAs Leads to Enhanced Paclitaxel Sensitivity in Epithelial Ovarian Cancer Chemotherapy. ACS Biomater Sci Eng. 2020 Jul 13;6(7):4036-4050. doi: 10.1021/acsbiomaterials.0c00330. Epub 2020 Jun 3. PMID: 33463352.

25.Zheng GM, Yu C, Yang Z. Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. Int J Oncol. 2012 May;40(5):1610-8. doi: 10.3892/ijo.2012.1331. Epub 2012 Jan 13. PMID: 22246431.

26.Lin A, Yin J, Cheng C, Yang Z, Yang H. Decreased expression of FOXA2 promotes eutopic endometrial cell proliferation and migration in patients with endometriosis. Reprod Biomed Online. 2018 Feb;36(2):181-187. doi: 10.1016/j.rbmo.2017.11.001. Epub 2017 Nov 22. PMID: 29233503.