个人简介 Personal Profile
左中,男,1972年9月出生,汉族,重庆人,研究生学历,博士,教授、心血管内科主任医师,美国俄克拉荷马大学医学中心(OUHSC)访问学者;爱体育「中国」官方网站附属第一医院第一分院院长,硕士生导师。
左中教授聚焦于衰老和肿瘤心脏病的临床和分子机制研究,取得了一系列原创成果,相关研究以通讯(含共同)作者发表在Small Methods、 Front Oncol、Age、Scientific Reports 、Journal of the American College of Cardiology、 Am J Cancer Res、Cardiovasc Toxicol等国际专业领域杂志20余篇。作为项目负责人主持省部级课题4项(重点项目2项)、厅局级课题3项,参研国家自然科学基金项目3项。致力于心电可穿戴设备的研发应用,指导学生获创新创业大赛国赛铜奖、市赛金奖1项。获2022年度重庆市科技进步奖二等奖1项。
工作经历
2024.03 至 今 爱体育「中国」官方网站附属第一医院心内科主任医师、教授,爱体育「中国」官方网站附属第一医院第一分院院长
2017.12 至 2024.02 爱体育「中国」官方网站附属第一医院心内科主任医师、教授,爱体育「中国」官方网站附属第一医院金山医院副院长
2011.12 至 2017.11 爱体育「中国」官方网站附属第一医院心内科副主任医师、副教授,爱体育「中国」官方网站附属第一医院金山医院副院长
1995.07 至 2011.11 爱体育「中国」官方网站附属第一医院心内科住院医师、主治医师、讲师
教育经历
2009.02 至 2010.05 美国俄克拉荷马大学医学中心(OUHSC)访问学者
2007.09 至 2011.06 爱体育「中国」官方网站内科学(心血管病学)博士研究生
1999.09 至 2002.06 爱体育「中国」官方网站内科学(心血管病学)硕士研究生
1990.09 至 1995.06 华西医科大学临床学院 本科学习
研究方向 Research Interests
在接下来的研究中将在以下几个方面开展工作:
(1)血管衰老的分子机制研究
(2)肿瘤心脏病的临床和基础研究
(3)心电智能监测适老化改造、衰老损伤标志物检测创新研发
实验室科研项目 Projects
在研科研项目
(1)爱体育「中国」官方网站未来医学青年创新团队计划,批号:No. W0188,2023.3.1-2026.2.28,30.0万,主持:
(2)重庆市科卫联合医学科研重点项目:免疫检查点抑制剂相关性心血管毒性的多模态临床检测及疾病风险模型构建,批号:2023ZDXM011,2023.1.1-2025.12.31,20.0万,主持。
已结题项目
(1)重庆市自然科学基金面上项目,心肌PPARγ2异常高表达导致心肌肥厚的机制研究,批号:cstc2019jcyj-msxmX0433,2019.07.01-2022.06.30,10.0万,主持;
(2)重庆市科卫联合医学科研重点项目,肿瘤靶向治疗所致心血管毒性的早期识别和危险因素筛查的临床研究,批号:2018ZDXM010,2018.01.01-2021.06.30,10.0万,主持;
(3)重庆市科委课题,cstc2013jcyjA10056,炎症信号上调miR-33:动脉粥样硬化斑块内胆固醇沉积的新机制,2013.07.01-2015.06.30 ,5.0万,主持 。
(4)重庆市体育局课题,智能心电衣对运动员运动性心律失常筛查和管理的初步应用研究,,批号:D202127,2021.10-2023.09,2.0万元,主持;
(5)重庆市渝中区科委课题:急性冠脉综合征易损斑块生物标志物的电化学传感检测新方法
研究,批号:20130131,2013.09.01-2015.08.31 4.0万,主持 ;
代表性科研论文 Publications
( *:co-corresponding authors 共同通讯作者; #:co-first authors 共同第一作者)
1.Yujuan Wu, Diansa Gao ,Li Tan, Zhulu Chen, Chuan Zhang,Min Mao,Yuxi Zhu,Yue Liu,Zhong Zuo. Natural killer cell as a potential predictive biomarker for early immune checkpoint inhibitor-associated cardiovascular adverse events: a retrospective cohort study . Front Oncol., 16 July 2025Sec.doi.org/10.3389/fonc.2025.1556373
2.Jialian Li,Zulu Chen,Yuxi Zhu,Gui Li,Yanwei Li,Rui Lan, Zhong Zuo. Predicting 30-Day Cardiotoxicity in Patients Receiving Immune Checkpoint Inhibitors: An Observational Study Utilizing XGBoost. Cardiovasc Toxicol. 2025 Apr 10.doi: 10.1007/s12012-025-09990-6. Online ahead of print.
3.Jialian Li, Yanwei Li, Li Tao, Chuan Zhang, Zhong Zuo. Diagnostic and Prognostic Value of Cardiac Magnetic Resonance for Cardiotoxicity Caused by Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis. Rev. Cardiovasc. Med. 2025, 26(2), 25508. https://doi.org/10.31083/RCM25508
4.Yanwei Li , Zhulu Chen , Rui Lan , Tao Ran, Jingyi He , Jialian Li , Qiuyue Shi , Min Mao , Zhong Zuo .Atherosclerotic renal artery stenosis, mediating biomarkers, and risk of cardiac among individuals with hypertension: A real-world study. IJC Heart & Vasculature 55 (2024) 101556 https://doi.org/10.1016/j.ijcha.2024.101556
5.Zhulu Chen, Rui Lan, Tao Ran, LiTao, Yuxi Zhu, Yanwei Li, Chuan Zhang, Min Mao, DiansaGao & Zhong Zuo A multimodality score strategy for assessing the risk of immune checkpoint inhibitors related cardiotoxicity。Scientific Reports , (2024) 14:24821 https://doi.org/10.1038/s41598-024-76829-5
6. Chunyang Li , Yujian Li, Shaoyan Wu, Gui Li, Juan Li, Yan Zhao, Huan Cai, Jia Shu, Mingxuan Song, Qing Fu, Jianbo Yuan, Xin Gao, Zhujun Ai, Xiaosong Li, Rui Chen, Zhong Zuo . Flexible Scaffold Modulation of Spatial Structure and Function of Hierarchically Porous Nanoparticle@ZIF-8 Composites to Enhance Field Deployable Disease Diagnostics . Small Methods 2024 Jul 31:e2400738 doi: 10.1002/smtd. 202400738
7.Tao Ran,Jinyao Chen,Qiurui She,Yi Mu,Min Zhang,Min Mao,Zhong Zuo,Juan Li. Anthracycline-induced arrhythmias in breast cancer therapy: A meta-analysis of single-arm trials. PLoS One. 2024 May 23;19(5):e0303208.
8.Zhulu Chen,Chuan Zhang,Yuxi Zhu,Diansa Gao,Min Mao,Zhong Zuo. Sacubitril/valsartan can improve the cardiac function in heart failure patients with a history of cancer: An observational study.Medicine (Baltimore). 2024 Mar 22;103(12):e37613
9.Chuan Zhang , Zhulu Chen, Shu Qin, Yuxi Zhu, Linjie Shu, Zhong Zuo. Incidence of Adverse Cardiovascular Events Associated with Immune Checkpoint Inhibitors and Risk Factors for Left Ventricular Dysfunction: A Single-center Prospective Clinical Study. Frontiers in Cardiovascular Medicine. 10:1052699. doi: 10.3389/fcvm. 2023.1052699
10.Hong Su , Diansa Gao , Yanlin Chen , Zhong Zuo. The Relationship Between Klotho and SIRT1 Expression in Renal Aging Related Disease. International Journal of General Medicine, 2022:15: 7885–789311.Xianyu Zhang ,Min Mao ,Zhong Zuo .Palmitate Induces Mitochondrial Energy Metabolism Disorder and Cellular Damage via the PPAR Signaling Pathway in Diabetic Cardiomyopathy. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022 :15:2287-2299
12.Yanlin Chen, Liangyong Deng, Jingbo Zhao, Tianwen Luo, Zhong Zuo. Extrauterine adenomyoma of the lesser omentum: Case report and review of the literature.Medicine, 2022,101(36):e30240